Sofosbuvir: MedlinePlus Drug Information

If sofosbuvir is taken in combination with ribavirin alone, it is usually taken for 12 or 24 weeks. If you have liver cancer and are waiting for a liver transplant, you will take sofosbuvir with ribavirin for up to 48 weeks or until you have a liver transplant. The length of your treatment depends on your condition, how well you respond to the medication, and whether you experience severe side effects. Do not stop taking sofosbuvir, peginterferon alfa, or ribavirin, unless told to do so by your doctor. In fact, there are several rather significant differences in the methodological approaches which are described and presented in detail in the papers [2, 3].

Cost-Effectiveness and Budget Impact of Hepatitis C Virus Treatment With Sofosbuvir and Ledipasvir in the United States

• Before taking sofosbuvir, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies.
• Eventually the 24-item CHEERS checklist was used to appraise the completeness of reporting of the case study [7].
• This condition is a viral infection that affects your liver.
• Sofosbuvir, in combination with ribavirin or peginterferon, must not be used during pregnancy by either the pregnant woman or her male partner.
• Sofosbuvir comes as a tablet that you can take by mouth with a glass of water as directed.

This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor’s approval. Sofosbuvir in combination with other antiviral medications reduces the amount of hepatitis C virus in the body and helps the body’s immune system fight the infection. It is not known if this treatment can prevent you from passing the virus to others.

Care options

• Do not take more or less of it or take it more often than prescribed by your doctor.
• Transparent VAF would therefore help to critically reflect and add new information.
• Sofosbuvir is an antiviral prescription medicine approved by the U.S.
• Men who are taking this medicine must avoid getting a woman pregnant while taking this medicine and for 6 months after stopping this medicine.
• The points addressed in this comment were to a large extent part of our own limitation section.

Ask your pharmacist or doctor for a copy of the manufacturer’s information for the patient. Talk to your doctor about the risk(s) of taking sofosbuvir. Copyright © 2024 Elsevier B.V., its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the Creative Commons licensing terms apply.

Why is this medication prescribed?

If you have diabetes, your blood sugar may be lower with hepatitis C treatment. This can increase your risk of low blood sugar, so your doctor may adjust your diabetes treatment plan. Tell your doctor right away if you have symptoms of low blood sugar such as sudden sweating, shaking, fast heartbeat, hunger, blurred vision, dizziness, or tingling hands/feet. The patent is held by the US drug firm Gilead Sciences, which markets sofosbuvir under the highly profitable brand name Sovaldi. Sofosbuvir is also a component of Harvoni and Epclusa, two other hepatitis C treatments marketed in Europe by Gilead Sciences. Germany is the largest pharmaceutical market in Europe, valued by Business Monitor International at around €40bn, although growth has been static (and slightly negative last year) due to changes to the national reimbursement regime.

What should I do if I forget a dose?

Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. If you are using this medication with ribavirin, it is recommended that female patients or female partners of male patients take a pregnancy test before starting this medication. See your doctor or health care professional for a follow-up visit as directed. You may need blood work while you are taking this medicine.

What should I tell my care team before I take this medication?

Tell your doctor if your symptoms do not improve or if they get worse. Continue to take sofosbuvir and your other antiviral medication(s) for the full length of time prescribed, even if your symptoms disappear after a short time. Stopping any of the drugs too early may result in a return of the infection.

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If you are taking this medication with food, open the packet(s) and pour the pellets into a small bowl with one or more spoonfuls of non-acidic soft food (such as pudding, mashed potato, ice cream). After gently mixing, take all of the mixture without chewing within 30 minutes. Take this medication by mouth with or without food as directed by your doctor, usually once daily. The dosage is based on your medical condition and response to treatment. Sofosbuvir must be used in combination treatment to have the best effect.

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Male patients should keep using birth control for 6 months after stopping treatment. If you or your partner becomes pregnant, or if you think you or your partner may be pregnant, tell your doctor right away. Sofosbuvir is an antiviral prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic hepatitis C virus infection (HCV) in adults and children 3 years of age and older who meet specific requirements, as determined by a health care provider. The points addressed in this comment were to a large extent part of our own limitation section.

The Socio-Economic Burden of Untreated Hepatitis C Virus Infected Patients in the Era of New Interferon-Free Therapy

• Ask your health care provider if changes in diet or medicines are needed if you have diabetes.
• Take monthly pregnancy tests while you are taking this medicine and for 6 months after this medicine is stopped.
• Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.
• Talk to your doctor if you think that you or your partner are pregnant or are trying to become pregnant.
• If you have diabetes, your blood sugar may be lower with hepatitis C treatment.

We agree that different clinical data might shift the efficiency frontier and lead to a different result, as might the consideration of other treatment alternatives. We would have welcomed a more thorough analysis of the current clinical evidence. Without guaranteeing completeness or drawing conclusions we have carried out a recent literature review, finding 39 papers (please see S1 Fig in S1 Appendix). We stated that our results cannot be used without restriction. For example, patient preference data was obtained from patients with experiences and attitudes difficult to compare from today’s perspective. We also mentioned in the limitation section that our study does not address how the aggregation of different patient groups is done.

What if I miss a dose?

Ask your health care provider if changes in diet or medicines are needed if you have diabetes. With the recombination of already published cost and effectiveness data only the last step is addressed in the paper. We had hoped for a more ambitious criticism, as each of these steps 1–6 requires a careful and cautious approach and has its limitations. Modifications in all remaining steps, especially scoring, weighting and aggregation will significantly affect the results. Against the background of the insinuations made, we would have expected more methodological depth and consider the uncritical acceptance of all our calculations to be questionable. Gandjour’s paper might have added some information when the models would have been adjusted to the current status of literature and the prices.

For this purpose, we published a case study for the practical implementation of the efficiency frontier to address methodological issues of scoring, weighting and aggregation. Sofosbuvir is used with other antiviral medications (such as ribavirin, peginterferon, daclatasvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. It works by reducing the amount of hepatitis C virus in your body, which may help your liver recover. Chronic hepatitis C infection can cause serious liver problems such as scarring (cirrhosis), or liver cancer. Researchers should be able to easily adapt the framework to add relevant elements that are specific and, such as disease-specific clinical or preference data. Transparent VAF would therefore help to critically reflect and add new information.

Do not take more or less of it or take it more often than prescribed by your doctor. The above information is intended to supplement, not substitute for, the expertise and judgment of your health care professional. You should consult your health care professional before taking any drug, changing your diet, or commencing or discontinuing any course of treatment. Sofosbuvir works with other medications to treat hepatitis C. This condition is a viral infection that affects your liver. Sofosbuvir comes as a tablet that you can take by mouth with a glass of water as directed.

We explicitly address the risk that significant patient groups are not included in the analysis and that an overall assessment cannot be derived. In order to illustrate the methodological approach, we focused on GT1 TN without cirrhosis. We also stated that we applied a simplified aggregation rule and that more complex functions should be tested in future evaluations. However, we wish to stress that our case study was published to demonstrate the application of patient preference information (PPI) in the efficiency frontier (EF). We clearly state, that we aim to demonstrate how an EF can be used to inform decision makers about “whether a treatment is efficient at given prices demonstrated through a case study on chronic hepatitis C“.

Drug Encyclopedia

Take sofosbuvir according to your health care provider’s instructions. Your health care provider will tell you how much sofosbuvir to take and when to take it. Before you start sofosbuvir and each time you get a refill, read any printed information that comes with your medicine. The weighted clinical data could have been varied in every respect to document a possible effect on the outcome and to see how results would flip. Anyway, we acknowledge that our reporting on the methods used for identification of included studies was incomplete (due to the limited number of studies available at the time of publication).

• Sofosbuvir pellets can be swallowed (without chewing) or they can be taken with food.
• Examples include apalutamide, rifamycins (such as rifampin, rifabutin), St. John’s wort, tipranavir/ritonavir, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone), among others.
• Food and Drug Administration (FDA) for the treatment of chronic hepatitis C virus infection (HCV) in adults and children 3 years of age and older who meet specific requirements, as determined by a health care provider.
• With some effort, a carryover with our data would have been possible and the data could have been compared with the clinical evidence now available.
• If you notice other effects not listed above, contact your doctor or pharmacist.
• Already at this point we must express our astonishment that these differences were not recognized while studying the underlying literature.
• Take the entire mixture within 30 minutes of sprinkling the pellets on food.
• Reliable forms of birth control must be used whenever at least one sexual partner is using these medicines together.

Ask your pharmacist any questions you have about refilling your prescription. Keep all appointments with your doctor and the laboratory. Your doctor may order certain tests before, during, and after your treatment to check your body’s response to sofosbuvir.

Read the Patient Information Leaflet and Instructions for Use if available from your pharmacist before you start taking sofosbuvir and each time you get a refill. If you have any questions, ask your doctor or pharmacist. Also read the drug information for your other antiviral medication(s).

Sofosbuvir faces fresh patent challenge in Europe

Other medications can affect the removal of sofosbuvir from your body, which may affect how sofosbuvir works. Examples include apalutamide, rifamycins (such as rifampin, rifabutin), St. John’s wort, tipranavir/ritonavir, drugs used to treat seizures (such as carbamazepine, phenobarbital, phenytoin, primidone), among others. Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

If any of these effects last or get worse, tell your doctor or pharmacist promptly. Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for selected conditions, precautions do apply.

To take this medication without food, open the packet and pour the pellets directly into your mouth. You may drink water after swallowing the pellets if needed. Repeat these steps if your dose is for more than one packet.

Meanwhile, discussions with GKV-Spitzenverband have gone to an arbitration procedure that is not expected to conclude until April at the earliest, although Gilead has indicated agreement could come at any time. German business magazine WirtschaftsWoche reported over the weekend that discounts have now been negotiated with 35% of Germany’s insurers, including AOK Rheinland/Hamburg, AOK Lower Saxony, Barmer GEK and Techniker Krankenkasse (TK). To learn how HIV and HCV are connected, read the HIVinfo HIV and Hepatitis C fact sheet. The fact sheet includes information about how HCV is spread, symptoms of HCV, and treatment options.

The country is home to an estimated 280,000 hepatitis C virus (HCV) infected patients. Lab tests (such as liver function, tests for hepatitis B and C) should be done before you start using this medication, while you are using it, and after completing treatment. Before taking sofosbuvir, enzalutamide price in thailand tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. If you are using the pellet form of this medication, gently shake the packet before use.

Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company. Store at room temperature away from light and moisture. For the pellets, do not open the packets until you are ready to use the medication. If you notice other effects not listed above, contact your doctor or pharmacist.

The most efficient compound resulting from the efficiency frontier was used as an example to calculate a net monetary benefit (NMB) and a price acceptability curve (PAC). It is important for you to keep a written list of all of the prescription and nonprescription (over-the-counter) medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements. You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies.

Although this medication is used to treat hepatitis C, it may rarely make another liver problem called hepatitis B get worse. Before starting this medication, tell your doctor if you have ever had hepatitis B. Tell your doctor right away if you have new or worsening symptoms of liver disease, such as nausea/vomiting that doesn’t stop, loss of appetite, stomach/abdominal pain, dark urine or yellowing eyes/skin.

Sofosbuvir may not prevent the spread of hepatitis C to other people. During pregnancy, sofosbuvir should be used only when clearly needed. Sofosbuvir, in combination with ribavirin or peginterferon, must not be used during pregnancy by either the pregnant woman or her male partner. Reliable forms of birth control must be used whenever at least one sexual partner is using these medicines together. Female patients should keep using birth control for 9 months after stopping treatment.

Our papers were intended to introduce and push forward this methodological discussion on aggregation, weighting, normalization of effects, consideration and interpretation of uncertainty and the use of preference data in HTA models. Sofosbuvir must be taken in combination with peginterferon alfa and ribavirin or in combination with ribavirin alone. If sofosbuvir is taken in combination with peginterferon alfa and ribavirin, it is usually taken for 12 weeks.